Cis-regulatory control of corticospinal system development and evolution
Nature 486, 7401 (2012). doi:10.1038/nature11094
Authors: Sungbo Shim, Kenneth Y. Kwan, Mingfeng Li, Veronique Lefebvre & Nenad Ε estan
The co-emergence of a six-layered cerebral neocortex and its corticospinal output system is one of the evolutionary hallmarks of mammals. However, the genetic programs that underlie their development and evolution remain poorly understood. Here we identify a conserved non-exonic element (E4) that acts as a
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