Justin Crocker's reading list...
Friday, May 24, 2013
The Genetic Basis of White Tigers
The Genetic Basis of White Tigers: Xiao Xu, Gui-Xin Dong, Xue-Song Hu, Lin Miao, Xue-Li Zhang, De-Lu Zhang, Han-Dong Yang, Tian-You Zhang, Zheng-Ting Zou, Ting-Ting Zhang, Yan Zhuang, Jong Bhak, Yun Sung Cho, Wen-Tao Dai, Tai-Jiao Jiang, Can Xie, Ruiqiang Li, Shu-Jin Luo. The white tiger, an elusive Bengal tiger (Panthera tigris tigris) variant with white fur and dark stripes, has fascinated humans for centuries ever since its discovery in the jungles of Ind....
Thursday, May 23, 2013
Paused Pol II Coordinates Tissue Morphogenesis in the Drosophila Embryo
Paused Pol II Coordinates Tissue Morphogenesis in the Drosophila Embryo: Mounia Lagha, Jacques P. Bothma, Emilia Esposito, Samuel Ng, Laura Stefanik, Chiahao Tsui, Jeffrey Johnston, Kai Chen, David S. Gilmour, Julia Zeitlinger, Michael S. Levine.
Paused RNA polymerase (Pol II) is a pervasive feature of Drosophila embryos and mammalian stem cells, but its role in development is uncertain. Here, we demonstrate that a spectrum of pause....
Paused RNA polymerase (Pol II) is a pervasive feature of Drosophila embryos and mammalian stem cells, but its role in development is uncertain. Here, we demonstrate that a spectrum of pause....
New Balance in Pluripotency: Reprogramming with Lineage Specifiers
New Balance in Pluripotency: Reprogramming with Lineage Specifiers: Uri Ben-David, Jonathan Nissenbaum, Nissim Benvenisty. Induction of pluripotency in somatic cells has been achieved by myriad combinations of transcription factors that belong to the core pluripotency circuitry. In this issue, Shu et al. report reprog....
Tuesday, May 21, 2013
GRN for neurogenesis in a sea star embryo [Developmental Biology]
GRN for neurogenesis in a sea star embryo [Developmental Biology]:
A great challenge in development biology is to understand how interacting networks of regulatory genes can direct the often highly complex patterning of cells in a 3D embryo. Here, we detail the gene regulatory network that describes the distribution of ciliary band-associated neurons in the bipinnaria larva of the sea...
A great challenge in development biology is to understand how interacting networks of regulatory genes can direct the often highly complex patterning of cells in a 3D embryo. Here, we detail the gene regulatory network that describes the distribution of ciliary band-associated neurons in the bipinnaria larva of the sea...
Ultraconserved words [Anthropology]
Ultraconserved words [Anthropology]: The search for ever deeper relationships among the World’s languages is bedeviled by the fact that most words evolve too rapidly to preserve evidence of their ancestry beyond 5,000 to 9,000 y. On the other hand, quantitative modeling indicates that some “ultraconserved” words exist that might be used to find...
Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation
Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation:
by Alexander Fleischmann, Ishmail Abdus-Saboor, Atef Sayed, Benjamin Shykind
The odorant receptor (OR) genes constitute the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion, through an unknown mechanism that likely exploits positive and negative regulation. We devised a genetic strategy in mice to examine OR selection by determining the transcriptional activity of an exogenous promoter homologously integrated into an OR locus. Using the tetracycline-dependent transactivator responsive promoter (teto), we observed that the OR locus imposes spatial and temporal constraints on teto-driven transcription. Conditional expression experiments reveal a developmental change in the permissiveness of the locus. Further, expression of an OR transgene that suppresses endogenous ORs similarly represses the OR-integrated teto. Neurons homozygous for the teto-modified allele demonstrate predominantly monoallelic expression, despite their potential to express both copies. These data reveal multiple axes of regulation, and support a model of initiation of OR choice limited by nonpermissive chromatin and maintained by repression of nonselected alleles.
by Alexander Fleischmann, Ishmail Abdus-Saboor, Atef Sayed, Benjamin Shykind
The odorant receptor (OR) genes constitute the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion, through an unknown mechanism that likely exploits positive and negative regulation. We devised a genetic strategy in mice to examine OR selection by determining the transcriptional activity of an exogenous promoter homologously integrated into an OR locus. Using the tetracycline-dependent transactivator responsive promoter (teto), we observed that the OR locus imposes spatial and temporal constraints on teto-driven transcription. Conditional expression experiments reveal a developmental change in the permissiveness of the locus. Further, expression of an OR transgene that suppresses endogenous ORs similarly represses the OR-integrated teto. Neurons homozygous for the teto-modified allele demonstrate predominantly monoallelic expression, despite their potential to express both copies. These data reveal multiple axes of regulation, and support a model of initiation of OR choice limited by nonpermissive chromatin and maintained by repression of nonselected alleles.
Friday, May 17, 2013
From neural development to cognition: unexpected roles for chromatin
From neural development to cognition: unexpected roles for chromatin:
Nature Reviews Genetics 14, 440 (2013).
doi:10.1038/nrg3508
Author: Jehnna L. Ronan, Wei Wu & Gerald R. Crabtree
Nature Reviews Genetics14, 347–359 (2013)In the above article, some of the references citations were incorrectly numbered in the 'Chromatin remodellers' section and in Table 1. This has now been corrected online. The editors apologize for this mistake.
Nature Reviews Genetics 14, 440 (2013).
doi:10.1038/nrg3508
Author: Jehnna L. Ronan, Wei Wu & Gerald R. Crabtree
Nature Reviews Genetics14, 347–359 (2013)In the above article, some of the references citations were incorrectly numbered in the 'Chromatin remodellers' section and in Table 1. This has now been corrected online. The editors apologize for this mistake.
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