Transcription factors: from enhancer binding to developmental control

Transcription factors: from enhancer binding to developmental control:
Transcription factors: from enhancer binding to developmental control

Nature Reviews Genetics 13, 613 (2012).
doi:10.1038/nrg3207

Authors: François Spitz & Eileen E. M. Furlong
Developmental progression is driven by specific spatiotemporal domains of gene expression, which give rise to stereotypically patterned embryos even in the presence of environmental and genetic variation. Views of how transcription factors regulate gene expression are changing owing to recent genome-wide studies of transcription factor