DNA-binding factors shape the mouse methylome at distal regulatory regions

DNA-binding factors shape the mouse methylome at distal regulatory regions:

DNA-binding factors shape the mouse methylome at distal regulatory regions

Nature 480, 7378 (2011). doi:10.1038/nature10716

Authors: Michael B. Stadler, Rabih Murr, Lukas Burger, Robert Ivanek, Florian Lienert, Anne Schöler, Christiane Wirbelauer, Edward J. Oakeley, Dimos Gaidatzis, Vijay K. Tiwari & Dirk Schübeler

Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet the rules that govern methylation patterns remain largely elusive. To gain insights into this process, we generated base-pair-resolution mouse methylomes in stem cells and neuronal progenitors. Advanced quantitative analysis identified low-methylated regions (LMRs)