Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence

Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence:

Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence

Nature Reviews Genetics 13, 59 (2012).
doi:10.1038/nrg3095

Authors: Patricia J. Wittkopp & Gizem Kalay

Cis-regulatory sequences, such as enhancers and promoters, control development and physiology by regulating gene expression. Mutations that affect the function of these sequences contribute to phenotypic diversity within and between species. With many case studies implicating divergent cis-regulatory activity in phenotypic evolution, researchers