The Majority of Animal Genes Are Required for Wild-Type Fitness

The Majority of Animal Genes Are Required for Wild-Type Fitness: Arun K. Ramani, Tungalag Chuluunbaatar, Adrian J. Verster, Hong Na, Victoria Vu, Nadège Pelte, Nattha Wannissorn, Alan Jiao, Andrew G. Fraser. Almost all eukaryotic genes are conserved, suggesting that they have essential functions. However, only a minority of genes have detectable loss-of-function phenotypes in experimental assays, and ....