Somatic coding mutations in human induced pluripotent stem cells
Nature 471, 7336 (2011). doi:10.1038/nature09805
Authors: Athurva Gore, Zhe Li, Ho-Lim Fung, Jessica E. Young, Suneet Agarwal, Jessica Antosiewicz-Bourget, Isabel Canto, Alessandra Giorgetti, Mason A. Israel, Evangelos Kiskinis, Je-Hyuk Lee, Yuin-Han Loh, Philip D. Manos, Nuria Montserrat, Athanasia D. Panopoulos, Sergio Ruiz, Melissa L. Wilbert, Junying Yu, Ewen F. Kirkness, Juan Carlos Izpisua Belmonte, Derrick J. Rossi, James A. Thomson, Kevin Eggan, George Q. Daley, Lawrence S. B. Goldstein & Kun Zhang
Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are integrated during some reprogramming methods, it is unknown whether the genome remains unchanged at the single nucleotide level. Here we show that 22 human induced
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