Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes: Warren A. Whyte, David A. Orlando, Denes Hnisz, Brian J. Abraham, Charles Y. Lin, Michael H. Kagey, Peter B. Rahl, Tong Ihn Lee, Richard A. Young. Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report....