High-throughput cis-regulatory element dissection [Systems Biology]

High-throughput cis-regulatory element dissection [Systems Biology]: Cis-regulatory elements (CREs) control gene expression by recruiting transcription factors (TFs) and other DNA binding proteins. We aim to understand how individual nucleotides contribute to the function of CREs. Here we introduce CRE analysis by sequencing (CRE-seq), a high-throughput method for producing and testing large numbers of reporter genes in...