Friday, September 28, 2012

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification: Robert M. Samstein, Aaron Arvey, Steven Z. Josefowicz, Xiao Peng, Alex Reynolds, Richard Sandstrom, Shane Neph, Peter Sabo, Jeong M. Kim, Will Liao, Ming O. Li, Christina Leslie, John A. Stamatoyannopoulos, Alexander Y. Rudensky.



Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage ....

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