Genome-wide structure and organization of eukaryotic pre-initiation complexes

Genome-wide structure and organization of eukaryotic pre-initiation complexes:
Genome-wide structure and organization of eukaryotic pre-initiation complexes

Nature 483, 7389 (2012). doi:10.1038/nature10799

Authors: Ho Sung Rhee & B. Franklin Pugh
Transcription and regulation of genes originate from transcription pre-initiation complexes (PICs). Their structural and positional organization across eukaryotic genomes is unknown. Here we applied lambda exonuclease to chromatin immunoprecipitates (termed ChIP-exo) to examine the precise location of 6,045 PICs in Saccharomyces. PICs, including RNA