Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription
Nature Reviews Genetics 13, 123 (2012).
doi:10.1038/nrg3124
Authors: Thomas Conrad & Asifa Akhtar
Dosage compensation is an epigenetic mechanism that normalizes gene expression from unequal copy numbers of sex chromosomes. Different organisms have evolved alternative molecular solutions to this task. In Drosophila melanogaster, transcription of the single male X chromosome is upregulated by twofold in a process
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