Transcription factor RBPJ/CSL: A genome-wide look at transcriptional regulation [Commentary]

Transcription factor RBPJ/CSL: A genome-wide look at transcriptional regulation [Commentary]: The transcriptional regulator RBPJ, otherwise known as CSL (“CBF-1, Suppressor of Hairless, Lag-2,” after its mammalian, Drosophila, and Caenorhabditis elegans orthologues) is a highly conserved DNA-binding protein that plays a central role in cell fate decisions in metazoa. RBPJ mediates canonical Notch signaling (1). In the absence of active Notch, RBPJ is thought to be primarily a transcriptional repressor that exists in complexes with corepressors (2). When bound to the active intracellular domain of Notch (NICD), RBPJ recruits a coactivator complex, including a Mastermind homologue (MAML1-3 in mammals), and drives a complex transcriptional program with pervasive phenotypic effects. This program...