Systems-biology approaches for predicting genomic evolution

Systems-biology approaches for predicting genomic evolution:

Systems-biology approaches for predicting genomic evolution

Nature Reviews Genetics 12, 591 (2011).
doi:10.1038/nrg3033

Authors: Balázs Papp, Richard A. Notebaart & Csaba Pál

Is evolution predictable at the molecular level? The ambitious goal to answer this question requires an understanding of the mutational effects that govern the complex relationship between genotype and phenotype. In practice, it involves integrating systems-biology modelling, microbial laboratory evolution experiments and large-scale mutational analyses