Determinants and dynamics of genome accessibility
Nature Reviews Genetics 12, 554 (2011).
doi:10.1038/nrg3017
Authors: Oliver Bell, Vijay K. Tiwari, Nicolas H. Thomä & Dirk Schübeler
In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome packaging inherently restricts DNA accessibility for regulatory proteins but also provides an opportunity to regulate DNA-based processes through modulating nucleosome positions and local chromatin structure. Recent advances in genome-scale methods are yielding increasingly
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