Impact of gene expression noise on organismal fitness and the efficacy of natural selection [Evolution]

Impact of gene expression noise on organismal fitness and the efficacy of natural selection [Evolution]: "Many cellular processes are subject to substantial stochastic variation, because they depend on interactions among a small number of molecules. For example, the transcriptional initiation of a gene in a haploid cell relies on the binding of the transcriptional machinery to a single DNA molecule. The stochastic nature of this and other molecular interactions results in a large variation in the expression of the same gene by different isogenic cells under the same environment (1–3). How and to what extent such molecule-level stochasticity affects the wellbeing of organisms and their evolution is not well-understood. Recent experimental characterization of gene expression..."