Ancient cis-regulatory constraints and the evolution of genome architecture: Manuel Irimia, Ignacio Maeso, Scott W. Roy, Hunter B. Fraser.
- Conserved gene order reveals constraints on cis-regulation and genome architecture.
- Hundreds of local gene associations have been conserved since the origin of animals.
- Constraints include coregulation and the formation of multigenic regulatory blocks.
- Establishment and disruption of regulatory blocks are highly dynamic in evolution.
- No conserved regulatory blocks have been found so far in non-animal eukaryotes.
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