Nature Reviews Genetics 14, 427 (2013).
doi:10.1038/nrg3473
Authors: Yosef Buganim, Dina A. Faddah & Rudolf Jaenisch
Conversion of somatic cells to pluripotency by defined factors is a long and complex process that yields embryonic-stem-cell-like cells that vary in their developmental potential. To improve the quality of resulting induced pluripotent stem cells (iPSCs), which is important for potential therapeutic applications, and to
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