Nature Reviews Genetics 14, 369 (2013).
doi:10.1038/nrg3512
Author: Hannah Stower
The threshold-dependent model predicts that morphogenesis programmes are executed by genetic networks that respond to absolute concentrations of transcription factors. To test this model, Liu et al. manipulated the absolute concentration of the transcription factor Bicoid in Drosophila melanogaster early embryos. Early on,
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