Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers: Jakob Lovén, Heather A. Hoke, Charles Y. Lin, Ashley Lau, David A. Orlando, Christopher R. Vakoc, James E. Bradner, Tong Ihn Lee, Richard A. Young. Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. Here, we i....