Dynamic regulatory network controlling TH17 cell differentiation

Dynamic regulatory network controlling TH17 cell differentiation:
Dynamic regulatory network controlling TH17 cell differentiation

Nature 496, 7446 (2013). doi:10.1038/nature11981

Authors: Nir Yosef, Alex K. Shalek, Jellert T. Gaublomme, Hulin Jin, Youjin Lee, Amit Awasthi, Chuan Wu, Katarzyna Karwacz, Sheng Xiao, Marsela Jorgolli, David Gennert, Rahul Satija, Arvind Shakya, Diana Y. Lu, John J. Trombetta, Meenu R. Pillai, Peter J. Ratcliffe, Mathew L. Coleman, Mark Bix, Dean Tantin, Hongkun Park, Vijay K. Kuchroo & Aviv Regev

Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term responses and relied on perturbation-based approaches that cannot be readily applied to primary T cells.