Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression: Lei S. Qi, Matthew H. Larson, Luke A. Gilbert, Jennifer A. Doudna, Jonathan S. Weissman, Adam P. Arkin, Wendell A. Lim. Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression ba....