Nature Reviews Genetics 14, 288 (2013).
doi:10.1038/nrg3458
Authors: Len A. Pennacchio, Wendy Bickmore, Ann Dean, Marcelo A. Nobrega & Gill Bejerano
It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.
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